BACE2 ELISA Kit for Human(Homo sapiens) | EIAab.comBACE2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BACE2(Gene name) > Human

BACE2 (Gene name),

Beta-secretase 2 (Protein name ), BACE2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BACE2(CDA13;UNQ418/PRO852;AEPLC;ALP56;ASP21);

Protein name:

Beta-secretase 2;

Alternative:

Aspartyl protease 1(ASP1;Asp 1);Aspartic-like protease 56 kDa;Down region aspartic protease(DRAP);Beta-site amyloid precursor protein cleaving enzyme 2(Beta-site APP cleaving enzyme 2);Membrane-associated aspartic protease 1;Memapsin-1;Theta-secretase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Interacts ith RTN3 and RTN4.

Function:

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Subcellular Location:

Membrane Single-pass type I membrane protein Golgi apparatus Endoplasmic reticulum Endosome Cell surface

Protein Attributes:

Sequence length:

518

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

518:

RDPEVVNDES | SLVRHRWK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:25825

STRING:

9606.ENSP00000332979

Pfam:

PF00026

UniGene:

Hs.43047

MIM:

605668

SMR:

Q9Y5Z0

UniGene:

Hs.529408

String:

Q9Y5Z0

Uniprot:

Q9Y5Z0

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ELISA Kit for Human Beta-secretase 2

Cat.:

E1812h

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96T

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ELISA Kit for Human Beta-secretase 2

Cat.:

E1812r

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96T

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ELISA Kit for Human Beta-secretase 2

Cat.:

E1812m

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Looking for manual.

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96T

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CLIA Kit for Human Beta-secretase 2

Cat.:

U1812m

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Packing:

96T

CLIA Kit for Human Beta-secretase 2

Cat.:

U1812r

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MSDS:

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96T

CLIA Kit for Human Beta-secretase 2

Cat.:

U1812h

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96T

Polyclonal Antibody for Human Beta-secretase 2

Cat.:

P1812Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Beta-secretase 2

Cat.:

P1812Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Beta-secretase 2

Cat.:

P1812Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Beta-secretase 2

Protein for Human Beta-secretase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity."
Yan R. , Bienkowski M.J. , Shuck M.E. , Miao H. , Tory M.C. , Pauley A.M. , Brashier J.R. , Stratman N.C. , Mathews W.R. , Buhl A.E. , Carter D.B. , Tomasselli A.G. , Parodi L.A. , Heinrikson R.L. , Gurney M.E.
Nature402:533-537(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION;TISSUE SPECIFICITY
2.

"Identification of a novel aspartic-like protease differentially expressed in human breast cancer cell lines."
Xin H. , Stephans J.C. , Duan X. , Harrowe G. , Kim E. , Grieshammer U. , Kingsley C. , Giese K.
Biochim. Biophys. Acta1501:125-137(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);AUTOCATALYTIC CLEAVAGE;INDUCTION;TISSUE SPECIFICITY;MUTAGENESIS OF ASP-110 AND ASP-303
tissue: Bone marrow.
3.

"A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase."
Solans A. , Estivill X. , de La Luna S.
Cytogenet. Cell Genet.89:177-184(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);TISSUE SPECIFICITY
4.

"The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region."
Acquati F. , Accarino M.P. , Nucci C. , Fumagalli P. , Jovine L. , Ottolenghi S. , Taramelli R.
FEBS Lett.468:59-64(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;GLYCOSYLATION
5.

"Expression analysis of BACE2 in brain and peripheral tissues."
Bennett B.D. , Babu-Khan S. , Loeloff R. , Louis J.-C. , Curran E. , Citron M. , Vassar R.
J. Biol. Chem.275:20647-20651(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
6.

"ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site."
Hussain I. , Powell D.J. , Howlett D.R. , Chapman G.A. , Gilmour L. , Murdock P.R. , Tew D.G. , Meek T.D. , Chapman C. , Schneider K. , Ratcliffe S.J. , Tattersall D. , Testa T.T. , Southan C. , Ryan D.M. , Simmons D.L. , Walsh F.S. , Dingwall C. , more...
Mol. Cell. Neurosci.16:609-619(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION
7.

"Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein."
Lin X. , Koelsch G. , Wu S. , Downs D. , Dashti A. , Tang J.
Proc. Natl. Acad. Sci. U.S.A.97:1456-1460(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
8.

Li Y. , Huang Q. , Peng Y. , Song H. , Yu Y. , Xu S. , Ren S. , Chen Z. , Han Z.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Pheochromocytoma.
9.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
10.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5)
tissue: Ovary.
tissue: Stomach.
11.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Skin.
14.

"Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes."
Sun X. , Wang Y. , Qing H. , Christensen M.A. , Liu Y. , Zhou W. , Tong Y. , Xiao C. , Huang Y. , Zhang S. , Liu X. , Song W.
FASEB J.19:739-749(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-47;FUNCTION
15.

"BACE2 functions as an alternative alpha-secretase in cells."
Yan R. , Munzner J.B. , Shuck M.E. , Bienkowski M.J.
J. Biol. Chem.276:34019-34027(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;AUTOCATALYTIC CLEAVAGE;FUNCTION;SUBCELLULAR LOCATION
16.

"BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome."
Sun X. , He G. , Song W.
FASEB J.20:1369-1376(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;FUNCTION
17.

"Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor."
Ostermann N. , Eder J. , Eidhoff U. , Zink F. , Hassiepen U. , Worpenberg S. , Maibaum J. , Simic O. , Hommel U. , Gerhartz B.
J. Mol. Biol.355:249-261(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 78-460;SUBUNIT;DISULFIDE BONDS
18.

"Prodomain processing of Asp1 (BACE2) is autocatalytic."
Hussain I. , Christie G. , Schneider K. , Moore S. , Dingwall C.
J. Biol. Chem.276:23322-23328(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOCATALYTIC CLEAVAGE;MUTAGENESIS OF ASP-110
19.

"Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein."
Murayama K.S. , Kametani F. , Saito S. , Kume H. , Akiyama H. , Araki W.
Eur. J. Neurosci.24:1237-1244(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RTN3 AND RTN4

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